The atherosclerosis-related cardiovascular diseases, such as coronary artery disease, stroke and peripheral artery disease, are the leading cause of death and morbidity in the United States and Europe. The pathophysiology of atherosclerotic plaque is essential to understand the criticality of these diseases and the correct functioning of pharmacological strategies. The use of statins, both primary and secondary prevention, it is well established in clinical practice based on scientific evidence; however, the use of aspirin in primary prevention is widely debated.
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